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By | February 23, 2021

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Generic Viagra, or Sildenafil, retails at a price roughly half that of the brand and is available at KwikMed in 100mg tablets. Be aware that the Sildenafil you many find available in 20mg dosages has not been approved for the treatment of Erectile Dysfunction but rather for the treatment of Pulmonary Hypertension. All prescriptions are dispensed by Physicians who are fully licensed by the appropriate authorities in their state of residence.

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Nasal congestion, including rhinitis, occurred in 4% of the patients receiving sildenafil for the treatment of ED in controlled clinical trials. Nasal congestion appears to be secondary to sildenafil-induced hyperemia of the nasal mucosa, which results from inhibition of mucosal PDE type 5 and resultant local vasodilation. Patients experiencing these hemorrhagic events had risk factors for hemorrhage, including concurrent anticoagulant therapy.

What Is Generic Viagra?

Rash, including maculopapular rash, has been reported in 2% of the patients with ED receiving sildenafil in controlled clinical trials. Abnormal liver function test results occurred in less than 2% of patients with ED receiving sildenafil in controlled clinical trials but have not been directly attributed to the drug.

Some men and their partners tolerate severe ED well, while others are severely distressed by even mild dysfunction. Patient assessment may also uncover related dysfunctions such as premature ejaculation, increased latency time associated with age, and psychosexual relationship problems. On December 11, 2017 the first generic version of Viagra® was made available by Teva Pharmaceuticals.

Use In Patients With Cardiovascular Disease

Data sources include IBM Watson Micromedex , Cerner Multum™ , ASHP and others. Of course, such an amazing property of Viagra, as a positive effect on potency, has a very simple and understandable scientific explanation that has nothing to do with magic, aphrodisiac or narcotics, no matter what some people think. In men suffering from erectile dysfunction, Viagra works by increasing blood flow to the penis, which facilitates the process of getting and keeping an erection hard enough for normal sexual intercourse.

  • Pretreatment with erythromycin , a specific CYP3A4 inhibitor, increased the AUC of a single 100-mg dose of sildenafil by 182%.
  • In a study in men with ED secondary to radical prostatectomy receiving fixed-dose sildenafil , response to therapy was greatest in those who had undergone bilateral-nerve-sparing surgery than in those who had undergone unilateral or non-nerve-sparing procedures.
  • At least 19 deaths have been reported in patients who may have taken sildenafil and who took or were given nitroglycerin or another nitrate/nitrite or who were found with nitroglycerin in their possession.
  • In specific drug interaction studies with some CYP3A inhibitors, exposure to sildenafil was increased by fivefold.
  • The point at which nitrates or nitrites can be given safely is unclear, and therefore the drugs should be avoided unless, in the view of the treating clinician, the benefits outweigh the risks.

This popular erectile dysfunction drug originally came on the market in 1998 as the first drug to treat impotence. It generated over a billion dollars in revenue in 2016 and has treated over 60 million men since it hit the market.

Common Side Effects

Improvement in erectile function sufficient for successful intercourse can be achieved with sildenafil in a substantial percentage of patients with ED, and the strength and duration of erection achieved with the drug in such patients approached those achieved in untreated healthy men. However, the dependence on adequate sexual stimulation for the erectile activity of sildenafil may not alleviate patient and partner performance pressures and therefore may limit efficacy in some patients. In addition, unlike intracavernosal or intraurethral therapy or vacuum constriction devices, selective PDE type 5 inhibitors are only effective in the presence of adequate sexual stimulation. Assessment of clinical need for therapy, including sildenafil, should take into account the psychologic effect on the man and his partner and an assessment of their needs and expectations of therapy.

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Rarely, cardiovascular effects may be severe enough to result in discontinuance of the drug, but the rate of discontinuance secondary to intolerable cardiovascular effects has been similar for sildenafil (0.9%) and placebo (0.9%) in controlled clinical trials for the treatment of ED. Sildenafil has been shown to remain effective for at least 0.5-3 years in controlled and uncontrolled studies. There currently are no specific limitations to continued sildenafil therapy based on patient age and/or duration of therapy alone. Sildenafil is administered orally for the treatment of erectile dysfunction . Administration of the drug with a high-fat meal decreases the rate but not extent of absorption, potentially delaying the onset of action of sildenafil. In part, the absence of an effect on sexual desire may be attributed to the fact that men enrolling in ED studies generally have a near-normal level of sexual desire upon study entry.

However, at least one court case has resulted in a product being taken off the market. At a lower dose, sildenafil is approved to treat pulmonary arterial hypertension—the higher dose is reserved for treating erectile dysfunction . Anawalt explains that there’s a chance your insurance might not cover it to treat ED. Men who have had a heart attack in the past six months, those taking nitrates for heart disease, and men taking protease inhibitors for an HIV infection shouldn’t take erectile dysfunction drugs, Bromberg said. And though rare, it is possible to have an erection that lasts for four hours or more. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

An agreement with Pfizer allowed Teva to begin to provide the generic drug in December 2017. Generic versions of this low-dose form of sildenafil have been available in the U.S. from a number of manufacturers, including Greenstone, Mylan, and Watson, since early 2013. Health care providers may prescribe generic sildenafil for erectile dysfunction. Acetildenafil and other synthetic structural analogs of sildenafil which are PDE5 inhibitors have been found as adulterants in a number of “herbal” aphrodisiac products sold over-the-counter.

Sildenafil Chart

However, not everyone knows what kind of disease the action of this medicine is directed against. It happens that the reason for the reduced potency lies in the imbalance of hormones or the lack of certain macro- or microelements in the body, as well as in trauma and its consequences.